Keep pc healthy?

I Scan for AntiVirus (Avast)

I Scan for Spyware (AdAware, Spybot, SuperAntiSpyware)

I Defragment It

I Clean the C Drive

I Use CCleaner

I Use IO Bit Personal Care

I use Spyware Blaster

Do i need anything else?

Keep pc healthy?hp

Wow,it should be running good. but I would switch from Avast to AVG7.5 free edition on the anti-virus. The only reason I say this is,Avast is good but cumbersome and slows your pc down whereas AVG will not slow down your pc and will let it start up faster. I have had it for 3 years now and not 1 virus has snuck by it. if you want to download it go to http://www.majorgeeks.com/AVG_Free_Editi...

Keep pc healthy?mcaffee

AVG free virus checker.
Sounds as if you have covered yourself. I don't see anything about a firewall though
You need to check C: for errors
Try moving your pagefile near the O.D. of the disk, then optimize it. Have you tried that? Or cleaning the registry.
Do you Have a Firewall ? Limit the programs that go through your firewall. The more programs the bigger the holes in the wall.